F19 NMR

In October 2021 IVAN will host a F19 Workshop.  Actual Date still to be determined.

Medicinal chemists might incorporate fluorine atoms into drug molecules to modulate attributes like biological activity or metabolic stability.  Modern methods have improved the chemist’s ability to integrate fluorine into synthetic schemes which, in turn, means that more than half of the molecules currently moving into development contain at least one fluorine atom.  The presence of 19F in a molecule engenders complexity for traditional NMR methods, but it also opens the possibility for new, powerful experiments.  The panel will show some examples from both categories and discuss methods to both overcome the complexity and exploit the unique properties of 19F for NMR analysis.

Panel Leader: Dave Russell