September 23 @ 1:00 pm - 3:00 pm EDT
In September 2021 IVAN will host a N15 NMR workshop. Actual Date still to be determined.
Nitrogen is ubiquitous, incorporated in small molecule natural products, pharmaceutical agents, and pharmacologically active peptides. 15N, the spin 1/2 isotope of nitrogen amenable to NMR observation, is notoriously challenging for direct observation with low natural abundance (0.37%) and, relatively speaking, a low observation frequency roughly 10% of the 1H NMR observation frequency on a given NMR instrument with experiments further exacerbated by a negative nOe. Nonetheless, beginning in the early 90’s, it became feasible to perform both one-bond and long-range 1H-15N heteronuclear shift correlation experiments on small samples. The panel discussion will address experiment choices and optimization as well as utilizing 15N NMR data in structure elucidation studies.