Time-Domian NMR Relaxometry

This IVAN Workshop on Time-Domain Relaxometry will be hosted by Marc Taraban of the University of Maryland.

There will be three presentations:

1. Dr. Leonid Grunin (Resonance Systems GmbH, Kirchheim/Teck, Germany)

Practical Time-Domain NMR of Solids for Routine Applications

Since the expanded modes of Data Analysis are coming into modern measurements techniques, the Time-Domain Nuclear Magnetic Resonance (TD-NMR) cannot stay aside the global trends. The talk describes various theoretical and practical aspects of building NMR relaxation experiments to allow maximal deriving of possible structure and dynamics information for different types of solids. Possible implementations of the Machine Learning and Multivariate Analysis approaches are considered as well.

2. Prof. Dr. Mecit Halil Öztop (Middle East Technical University, Ankara, Türkiye)

Investigation of the Quality Problems in Biotechnological Drugs by TD-NMR and Benchtop MRI

Time domain NMR (TD-NMR) and low-field magnetic resonance imaging (MRI) are widely used in the polymer, food, and pharmaceutical industries because the analysis time is shorter, the sample does not need preliminary preparation, and the cost is lower than NMR spectroscopy. Because biotechnology drugs are proteins or peptides, they are easily affected by changes in environmental conditions and are subjected to structural changes and further denaturation. These changes can jeopardize patient health by leading to deterioration of the quality of the active ingredient as well as excipients. Therefore, it is an important advantage to control the quality of the drug quickly and without prior preparation. Crystallization, aggregation, quantitative formulation errors, glycation, detection of amorphousness/crystallinity of lyophilized drugs are some of the important quality issues in biotechnological drugs that can be detected by TD-NMR and MRI. In this study, aggregation in Humulin-R under different stress conditions and quantitative analysis of Humulin-R and Humulin-N mixtures were investigated by TD-NMR and MRI. The results show that T 2 relaxation behavior can be linked to the aggregations formed in different stress types. Moreover, T 2 relaxation times and proton pools in T 1 -T 2 mapping showed significant differences between different ratios of Humulin R and Humulin-N.

3. Prof. Igor Mastikhin (University of New Brunswick, Fredericton, Canada)

Time-Domain, Portable NMR for Measurements of Dynamic Properties

Dynamic properties are defined as a response of a sample to an applied dynamic stress. A change in tissue elasticity can be an indication of health issues; a flow induced in response to shear stress can provide information on its viscosity, its (Non)-Newtonian index or a turbulence onset. In all these cases, there are time-dependent displacement distributions within the sample. Adding a permanent magnetic field gradient to the NMR-sensitive region will induce an NMR signal phase interference, resulting in the dynamic information encoded into the Time-Domain NMR signal. We will show how this approach can be implemented on portable NMR devices, with examples from elastometry, rheology, and turbulence studies.

Registration for this meeting is open: Time-Domain NMR Relaxometry – IVAN Workshop