Inspiring a Versatile and Agile NMR Community
Pure shift spectra (1D or 2D) by homonuclear BB decoupling are typically accomplished by selective inversion of passive spins midway between dwell points or chunks of dwell points during acquisition and the magnetization is sampled when all the multiplet vector trajectories are at or very near their chemical shift trajectory.[…]
The topic of our round-table workshop on February 26, 2026, was Automated Structure Verification: Balancing Speed and Accuracy in NMR Analysis. Advances in NMR instruments and methods now let scientists collect large amounts of 1D and 2D data very quickly. This leaves processing and interpreting that data as the bottleneck[…]
NMR is one of the best analytical tools for the quantification of samples and identification of unknown molecules. It is also a near-universal detector if the concentration of the analyte is sufficient. Given these great strengths, why is NMR metabolomics lagging LC-MS metabolomics? My answer is that both quantification and[…]
The topic of our round-table workshop on November 20, 2025, was Tracking Real-Time Proline Hydroxylation in IDPs? Just Tune Your NMR. Following post-translational modifications such as proline hydroxylation in intrinsically disordered proteins (IDPs) doesn’t have to be an ordeal. By harnessing 13C-direct detection combined with multi-receiver acquisition, we tracked Hypoxia-Inducible[…]
The topic of our round-table workshop on October 28, 2025, was A Quantum Inspired NMR Radio Frequency for Digital Health. In recent years, it has been discovered that heterogeneous diseases such as cardiovascular diseases, diabetes, hepatitis and cancer may be attacked effectively by developing specific treatment plans that are generally[…]
The topic of our round-table workshop on September 25, 2025, was The Power of 2D and 3D NMR, aided by good model compounds, for Assigning Structures in a Complex Natural Polymer Individual structures in a complex plant polymer’s HSQC spectrum are exquisitely revealed via an underutilized 2D-HSQC-TOCSY experiment. Extreme simplification[…]
The topic of our round-table workshop May 29, 2025 was i-HMBC Methodology: Applications and Enhancements In 2023, researchers at Merck & Co. Inc. reported the i-HMBC methodology which allows differentiation of 2JCH from 3+nJCH correlations based on comparative analysis of two-bond 2Δ1H(13/12C) and three-bond 3Δ1H(13/12C) isotope shifts. This innovation obviates[…]
The topic of our round-table workshop on February 27, 2025, at 4:00 PM ET USA was Suppress or not to Suppress?!… – CRAFT it ! – Extracting essential biomarker signals directly from the full 1H NMR spectrum of existing serum samples. The panel introduced a very efficient and powerful software[…]
Our round-table workshop on January 30, 2025 was on Hyperpolarized NMR for Complex Mixture Analysis. Analysis of complex mixtures is a common task in many branches of chemistry, be it a complex pharmaceutical formulation, a collection of biofluids analyzed in a metabolomics workflow, or a flowing mixture in a reaction[…]
On August 29, 2024, Dr. Puneet Bagga, St. Jude Children’s Research Hospital; Dr. Esin Ozturk Isik, Bogaziçi University and Dr. Aaryani Tipirneni-Sajja (panel leader), University of Memphis presented on advanced in vivo MRS/MRI techniques for brain and liver applications. Dr. Bagga discussed the development of a novel approach, Quantitative Exchanged[…]